Australian Research Institute: The effect of the new crown vaccine under development is not affected by the D614G mutation
Original title: Australian Research Institute: The effect of the new crown vaccine under development is not affected by the D614G mutation
Canberra, October 12 (Reporters Bai Xu and Yue Dongxing) The Australian Commonwealth Scientific and Industrial Research Organization recently issued a communiqué saying,A new study led by the agency found thatThe D614G mutation of the new coronavirus will not negatively affect the effectiveness of some new coronavirus vaccines under development.Related results have been published in the British “Natural Cooperation Journal·Vaccine” recently.
The new coronavirus strain carrying the D614G mutation is called “G strain”,Compared with the original strain “D strain”,The 614th amino acid on the spike protein was changed from aspartic acid (D) to glycine (G).
The bulletin introduced,At present, most of the new coronavirus vaccine candidates in the world are developed using the D strain of the original strain of the new coronavirus as a model.The latter is more common in viral genome sequences released early in the pandemic.however,The evolution of the virus that began at the beginning of the pandemic has gradually made the G strain gradually become the world’s major new coronavirus strain.Currently, it accounts for about 85% of all released new coronavirus genomes.There is a view thatThis mutation may adversely affect the effect of the new coronavirus vaccine under development.
In the latest research,Researchers from the Australian Commonwealth Scientific and Industrial Research Organization and other institutions vaccinated ferrets with the new crown vaccine INO-4800 developed by the US Inovio Pharmaceutical Company.And receive a certain dose of D strain or G strain of new coronavirus.Serum analysis of these ferrets showed thatThere is no evidence that the D614G mutation has a negative impact on the efficacy of the INO-4800 vaccine.
Through biomolecular modeling,The researchers further simulated the interaction between the vaccine and the virus.”Through visualization of molecular structure,We can support the inferences of this research,That is, the immune response generated by the candidate vaccine is equally effective against the D strain and G strain of the new coronavirus.”One of the authors of the paper, said Dr. Michael Kuiper.
Dr. Vassan, the senior author of the paper, said,This is good news for hundreds of new coronavirus vaccines that are currently under development worldwide.For viruses such as seasonal flu,It is also necessary to periodically develop new vaccines to protect against the virus strains that are spreading.After the new coronavirus has mutated, frequent “vaccine matching” may not be required.